Perlane is a hyaluronic acid filler that last longer than Restylane or Juvederm. The particle size is larger and there is more cross linking between the molecules. Perlane is made by Medicis.
This filler is also ideal for lips, nasolabial furrows, or cheek depressions. It is typically injected slightly deeper in the dermis because of the increased thickness.
Although the manufacturer will state that the filler last up to one year, Dr Mandell-Brown believes that whatever length of time you hear on TV, radio, or advertisements, you should subtract 50 %. Based on this 50% rule, Perlane typically lasts from 3 to 6 months.